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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
15.45
Human Site:
T597
Identified Species:
24.29
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
T597
S
Q
R
G
R
A
D
T
G
L
E
T
S
T
R
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
T597
S
Q
R
G
R
A
H
T
G
L
E
T
S
T
R
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
T597
S
Q
R
G
R
V
G
T
G
L
E
T
S
T
R
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
T596
G
S
Q
R
G
R
D
T
G
L
E
I
T
T
R
Rat
Rattus norvegicus
Q9JIM0
706
80103
T596
G
S
Q
R
G
R
D
T
G
L
G
I
S
T
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
G596
A
R
G
G
A
R
R
G
R
G
S
S
C
Q
E
Chicken
Gallus gallus
Q9IAM7
700
80005
R590
A
A
R
G
S
S
R
R
G
R
G
N
T
S
Q
Frog
Xenopus laevis
Q9W6K1
711
81112
G594
G
T
S
R
R
G
R
G
S
A
S
A
D
Q
P
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
R508
D
E
E
I
R
Q
F
R
D
S
K
R
N
T
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
N507
E
A
M
P
N
D
E
N
I
D
E
E
L
E
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
V604
S
E
R
F
K
N
P
V
A
D
V
E
M
E
E
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
F405
Q
L
K
K
E
G
E
F
I
L
F
L
S
I
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
G595
T
T
L
D
S
S
L
G
F
R
Q
S
Q
R
S
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
S582
T
H
I
S
Q
A
E
S
S
K
P
T
S
K
P
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
K617
A
K
K
A
A
P
G
K
K
A
A
P
A
K
K
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
93.3
N.A.
86.6
N.A.
46.6
46.6
N.A.
6.6
20
6.6
13.3
N.A.
13.3
N.A.
13.3
13.3
P-Site Similarity:
100
93.3
N.A.
86.6
N.A.
60
53.3
N.A.
26.6
53.3
6.6
33.3
N.A.
20
N.A.
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
0
20
0
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
46.6
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
14
0
7
14
20
0
0
7
14
7
7
7
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% C
% Asp:
7
0
0
7
0
7
20
0
7
14
0
0
7
0
0
% D
% Glu:
7
14
7
0
7
0
20
0
0
0
34
14
0
14
14
% E
% Phe:
0
0
0
7
0
0
7
7
7
0
7
0
0
0
0
% F
% Gly:
20
0
7
34
14
14
14
20
40
7
14
0
0
0
0
% G
% His:
0
7
0
0
0
0
7
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
7
0
0
0
0
14
0
0
14
0
7
0
% I
% Lys:
0
7
14
7
7
0
0
7
7
7
7
0
0
14
7
% K
% Leu:
0
7
7
0
0
0
7
0
0
40
0
7
7
0
0
% L
% Met:
0
0
7
0
0
0
0
0
0
0
0
0
7
0
0
% M
% Asn:
0
0
0
0
7
7
0
7
0
0
0
7
7
0
7
% N
% Pro:
0
0
0
7
0
7
7
0
0
0
7
7
0
0
14
% P
% Gln:
7
20
14
0
7
7
0
0
0
0
7
0
7
14
7
% Q
% Arg:
0
7
34
20
34
20
20
14
7
14
0
7
0
7
40
% R
% Ser:
27
14
7
7
14
14
0
7
14
7
14
14
40
7
7
% S
% Thr:
14
14
0
0
0
0
0
34
0
0
0
27
14
40
0
% T
% Val:
0
0
0
0
0
7
0
7
0
0
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _